Vanderbilt Center for Structural Biology Cryo Electron Microscopy Facility

Overview 

The goal of the Center for Structural Biology Cryo Electron Microscopy Facility is to make molecular EM accessible to all interested researchers at Vanderbilt. Molecular-EM is one of the fastest developing, cutting-edge structural techniques for exploring the organization of biological macromolecules. The unique strength of molecular EM is its versatility. Structures determined using molecular EM can span resolution ranges from very low- to atomic-levels (>30–1.8Å) and do not require crystalline samples for analysis. The CSB Cryo-EM Facility provides researchers with access to state-of-the-art equipment, training and expert technical support for high resolution data collection and structural analysis of biological specimens using single particle analysis and tomography. This support ranges from specimen preparation, data collection, image processing, computational image analysis, and structure determination.

 

Services Offered

  • Transmission electron microscopy
  • Cryo-transmission electron microscopy
  • Negative staining with uranyl formate
  • Sample vitrification
  • Data processing and analysis
  • Expert training and consulting on equipment operation, sample preparation, and data analysis

 

Leadership

Melissa Chambers Scott Collier
Director Director
615-322-4671 615-322-4671
melissa.g.chambers@vanderbilt.edu scott.e.collier@vanderbilt.edu 

 

Locations and hours of operation

Hours Locations
Open: Staffed:
24/7 Monday-Friday, 9am-4pm
24/7 Monday-Friday, 9am-4pm
24/7 Monday-Friday, 9am-4pm

 

     
MCN RR1207 1161 21st Ave S Nashville TN 37232
MRB3 4149A 465 21st Ave S Nashville TN 37232
ESB 003 2412 Highland Ave Nashville TN 37232

 

Links and Resources

  1. CSB Cryo-Electron Microscopy Facility

Contacts

Name Role Phone Email Location
Emma Pacilli
Core Admin
 
(615)343-3182
 
emma.pacilli@vanderbilt.edu